The Accordion Pill™

this is altThe Accordion Pill™ is a unique gastro retentive formulation composed of pharmaceutical (IIG listed) biodegradable polymeric films. It is a multi-layer, planar structure, folded to an accordion shape into a standard size, regular capsule.


Upon reaching the stomach, the capsule dissolves, the Accordion Pill™ unfolds and is retained in the stomach for up to 12 hours, under regular calorie diets. While in the stomach, the Accordion Pill™ releases the drug in a controlled manner towards the upper part of the gastrointestinal tract.

  • The drug release mechanism is independent of the Accordion pill™ retention mechanism
  • Once the Accordion Pill™ is expelled from the stomach, it is fully degraded in the intestine.
  • The Accordion Pill™ can combine immediate and controlled-release profiles and can contain more than one API.
  • High drug loading, up to 550mg.

The Accordion Pill™ safety and efficacy were tested in more than 30 clinical studies, with more than 3,000 administrations.

Retaining the dosage form in the stomach and releasing the drug in a controlled manner enable prolonged and continuous absorption phase of the drug in the upper part of the gastrointestinal tract, resulting in improved efficacy and safety profile, as well as reducing frequent daily dosing.

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The Accordion Pill™ is designed for drugs that are characterized by one or more of the following:

  • Narrow absorption window (poor colonic absorption).
  • Poor solubility, BCS (Biopharmaceutics Classification System) Class II or Class IV.
  • Act locally, in the stomach or in the upper part of the GI tract.
  • Adverse effects correlate with the drug reaching to the distal parts of the GI tract.